Trace minerals: Consider the source of these essential nutrients!

Dairy Mail, November 2022

Trace minerals such as copper (Cu), zinc (Zn), manganese (Mn), and selenium (Se) are vital for optimal health and performance. An optimal trace element supply, provided by a high-quality source of trace minerals, is necessary to avoid deficiencies and associated health issues. New generation trace minerals (hydroxy Cu, Zn, Mn, and L-selenomethionine) are highly available to the animal. They contribute to a secure trace mineral supply to the animal, which results in improved animal health and performance.

Characteristics of high-quality trace minerals

An important characteristic of high-quality trace mineral sources is the availability of the trace element at the right place, at the right time, where it can be absorbed by the animal. For ruminants, it is required that the reactivity of trace elements in the rumen is low. Specifically minimal levels of reactive Cu and Zn should be present for a good fibre fermentation and volatile fatty acid (VFA) production by the rumen microbiota. In a recent in vitro trial, this low reactivity of hydroxy Cu and Zn was demonstrated. In a simulation of rumen fermentation, the influence of multiple sources of Cu and Zn were tested, at a dosage providing from each source the same additional level of Cu and Zn. Of all sources tested, the hydroxy trace elements were the only ones that did not influence the total VFA production during fermentation (Graph 1). For the sulphate and for the three tested organic sources (glycinate, amino acid-complex, and proteinate), a significant decrease in total VFA production was observed compared to the unsupplemented control, indicating inhibition of fermentation by trace element reactivity.

Under practical circumstances, impaired efficacy of the rumen microbiota by toxic antimicrobial effects of soluble, reactive Cu and Zn, will result in lower ruminal fibre fermentation, and reduced animal performance and health. An important characteristic of L-sele-nomethionine, on the other hand, is its abil-ity to circumvent the reducing power of the Se-reducing microbes that reside in the ru-men. These organisms can reduce, specifi-cally, inorganic Se into elemental Se, which is non-soluble and, therefore, excreted to a high extent. This reaction explains why inor-ganic Se is not able to fulfil the nutritional requirements of ruminants (Hosnedlova et al., 2017).

In a recent ex vivo trial, it was proven that when L-selenomethionine is used instead of inorganic Se sources, this resulted in far less elemental Se formation. Moreover, L-selenomethionine was incorporated to a greater extend into rumen microorganisms (Graph 2). L-selenomethionine is a unique molecule as it has the ability, as an amino acid, to be incorporated into animal and bacterial proteins. Lysis of rumen microorganisms in the abomasum liberates high-quality microbial protein, including L-selenomethionine, which will be readily available for absorption in the small intestine, ensuring a Se reserve in ruminant tissues.

Higher availability as a condition for economic yield

Low reactivity and subsequent high availability are important high-quality characteristics of hydroxy Cu, Zn, and Mn. As a result, in various animal trials, both under practical and controlled conditions, hydroxy trace minerals show higher rumen fermentation, dry matter digestibility, milk production, and (claw) health. Replacing sulphates, oxides, and chelates with hydroxy trace minerals has also shown improved fertility. This has been expressed as a higher percentage of successfully inseminated cows at first service, reduced interval calving/successful insemination, and lower percentage of cows needing more than three inseminations. These fertility improvements result in an important cost saving for the farmer.

Stressful periods (e.g., periparturient period, heat, weaning) are plentiful during life and always correlated with an increase in oxidative stress. To combat this stress, the animal needs high bioavailable Se. The periparturient period presents a big challenge to ruminants as they transition from late gestation to early lactation. The calving process and the increased metabolic activity and energy demand that marks this period, are linked to a high increase in oxidative stress. In literature, it is seen that supplementation of organic Se to Se-adequate cows during late gestation improves antioxidant function in early lactation. This leads to effective attenuation of oxidative stress. Plasma malondialdehyde, which is a biomarker for lipid peroxidation, and reactive oxygen species levels are lowered significantly postpartum with organic Se supplementation. The plasma total antioxidant capacity (T-AOC) is also significantly improved. These results show that storable Se has a big positive impact during stressful periods. Positive effects for organic Se are also seen for the immune system (e.g., neutrophils). This effect is beneficial in improving the mammary gland health, where the primary defense mechanism is the phagocytic activity of neutrophils and lowering the somatic cell count.

Birth to weaning also presents a huge challenge for calves and stress reduction is key. To enhance the Se status of calves during the first weeks, Se transfer from cows to their offspring via colostrum/milk is essential. When the effect of supplementation of different sources of Se on the Se concentrations in milk from dairy cattle was investigated, L-selenomethionine increased the milk Se level to the highest extend throughout the whole trial period (Vandaele et al., 2014).


To supplement feed with trace elements, it is important to choose a high-quality trace mineral source to guarantee the best supply of these essential nutrients to the animal. Hydroxy trace minerals and L-selenomethionine (Excential Smart & Excential Selenium 4000, Orffa Additives BV, The Netherlands), with no impact on rumen functioning, provide your animals with these nutrients in a safe and optimal way.