Mycotoxins are toxic secondary metabolites of various strains of molds. More than 400 types of mycotoxins are known and FAO estimated that 25% of the world feed cereals are contaminated by mycotoxins. Commercial mycotoxin management preparations are (partially) based on adsorbents. These adsorbents are able to bind, to a certain extent, specific mycotoxins in the gastrointestinal tract. Adsorption of mycotoxins is a valid strategy, but complete binding is not achievable. Therefore other defense mechanisms should also be considered such as intestinal integrity support and mold inhibition.